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May (53:05/06)

A tiny egg with a big impact: how could proteases and inhibitors influence Schistosoma mansoni egg-host interaction?

A new study investigates the proteases and inhibitors involved in the interaction between Schistosoma mansoni eggs, responsible for the pathological manifestations of schistosomiasis, and their mammalian hosts. The study compares S. mansoni eggs with those of Fasciola hepatica, a related liver fluke that does not cause the same tissue pathology. By employing RNA-seq comparative transcriptomics, the study identifies 135 proteases and 21 inhibitors in S. mansoni eggs, while only 117 proteases and 16 inhibitors are identified in F. hepatica eggs. The distinct expression profiles of these two species reveal new potential participants in the egg-host interplay, specifically involved in regulating host hemostasis, immunity, neovascularization, and egg migration.

Peterkova, K., Vorel, J., Ilgova, J., Ostasov, P., Fajtova, P., Konecny, L., Chanova, M., Kasny, M., Horn, M., Dvorak, J., 2023. Proteases and their inhibitors involved in Schistosoma mansoni egg-host interaction revealed by comparative transcriptomics with Fasciola hepatica eggs. Int. J. Parasitol. 53, 253-263.